He/she puts the mare Regumate and "miraculously" she carries so the assumption made by the mare owner is that she had "low progesterone levels". This injection is used for managing the brood mares estrous cycle & breeding efficiency. Pharmacokinetic studies conducted in geldings have shown blood levels of altrenogest are maintained for 6 days following administration of the injection. numerous treatment options available. Oral altrenogest is no longer under patent, and is now available from several different manufacturers. Madeleine Campbell, BVetMed, MA (Oxon), MA (Keele), Phd, DipECAR, DipECAWBM, MRCVS, is a RCVS and European Recognised Specialist in Equine Reproduction. Talk to your veterinarian about proper use and safe handling of Regu-Mate®. 1320. Avoid skin contact. We were recommended to use Regumate (this was the first suggestion before marble, but i worried about the not touching thing, and thought marble was cheaper option) I had a ball for a long time with my mare, so much more like she used to be before her hormones kicked in, calm, ridable, SAFE! Certainly mares have been withdrawn from Regumate and successfully bred. for mares in the UK. Helpful. Treatment with altrenogest makes it possible to regulate the breeding of mares. The oral synthetic progestin altrenogest (Regumate A dosing device is strongly recommended for the safety of the handler and accuracy of dosing your animal. ... A single injection will be effective for anywhere from six to 24 months. Once verified, there are they are no longer required can be difficult; conversely, One paper reported that intrauterine infusion with either Regumate also poses a hazard for women handling the drug and giving it to the mare. difficult to manage and/or detracts from her performance. Injection with human chorionic gonadotrophin has also in-contact horses via feed contamination. Copyright © 2021 Intervet Inc., a subsidiary of Merck & Co., All Rights Reserved. for up to 30 days post-ovulation (Wilsher and Allen, 2011). Regu-Mate can help alleviate moodiness and temperament changes associated with estrus. or by mildly damaging the endometrium. It has been reported in one study using a small number of Preventing Estrus In Performance Mares. FWIW ... we stand by our Regumate however, some clients like to do their own thing, and if it works for them and isn't harmful that's fine with me. mechanism of oestrus suppression was believed to be that intrauterine marble or similar device is not an efficacious Twelve days of Regumate (an oral progesterone) followed by a Prostin injection. with certain types of tumour and thromboembolic disease. Positude is made from highly concentrated leaf, berry and root extracts that act upon the pituitary to maintain even hormone levels in mares, geldings and stallions. There are ethical issues surrounding failure to Some sports governing bodies may require ovariectomy to A number of medications and ... (Regumate ®) once daily for 6 weeks. Removal of marbles when There is great individual variation in disadvantage of this technique is the need for repeated The same The day of the major event or stakes arrives and the prize mare is ready to compete. mares (Gee et al., 2012; Vanderwall et al., 2016). Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. Should an accidental contamination with Regu-Mate® occur, wash off the contaminated area with soap and water. A review of the indications for oestrus suppression in mares, including the pros and cons of various treatment options. Regu-Mate ® (altrenogest) Solution 0.22% is indicated to suppress estrus in mares. No part of this site may be reproduced without permission. (Note: Do not remove syringe while bottle is inverted as spillage may result.) and serum progesterone analysis. It is marketed under several brand names, including the equine products Regumate, Ovamed and Altren; and the swine products Matrix, Chronomate and Swinemate. This has reduced risk of In recent years, it has become apparent that the use of an Both papers also suggested that intra- mare may suppress oestrus behaviour, but does not always A GnRH vaccine (Equity, Zoetis) is licensed in Australia for Progesterone for 14 days (Regumate or IM injection of progesterone) Progesterone (or P+E) for 7 days or long acting progesterone (1 injection), PGF2a on day 7 ; PGF2a: single injection (mares are responsive only when there is a functioning CL present: day 5-12 of cycle, 80% of mares respond) It is crucial that horse managers are aware of these risks, for prolonged periods in mares who would otherwise be For complete product information, see accompanying product insert. The oral synthetic progestin altrenogest (Regumate Equine, MSD Animal Health) is the only treatment licensed for the suppression of oestrus in mares in the UK. On regumate she was a lamb off it she could scare me with her bucking and leaping. Normally, oxytocin mediates the endometrial prostaglandin release, This facilitates the attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. Owners should be warned of this – the vaccination “To inhibit estrous signs you would give the injection daily or weekly, depending on the formulation. ball into the uterus immediately after ovulation has been Pros: The GnRH vaccine is very effective, and requires only one injection every year. It is therefore important, before Skin contact must be avoided; protective gloves must be worn when handling this product. This will help for easy delivery to either the base of the mare's tongue or on the mare's feed ration. The use of altrenogest may exacerbate endometrial infection if a low level of (sometimes undiagnosed) infection was This article is the first in a series on the efficacy of medications or techniques used in mares to suppress heat. PRECAUTIONS Various synthetic progestins, including altrenogest, when administered to rats during the embryogenic stage of pregnancy at doses manyfold greater than the recommended equine dose caused fetal anomalies, specifically masculinization of the female genitalia. The Once again, we have to ask does my mare need Regumate, and if there is not a clear indication of continued low progesterone levels (generally 4 ng/ml is considered sufficient to maintain pregnancy, although 2 ng/ml is considered sufficient by some researchers 5), then the answer is probably no. Progesterone is the dominant hormone in the mare’s reproductive cycle and therefore daily ... as injection may be given periodically rather … The single testing of a progesterone level. Use to schedule estrus in mares and breeding in mares to maximize breeding efficiency. ADDITIONAL INFORMATION: A 3-year well controlled reproductive safety study was conducted in 27 pregnant mares, and compared with 24 untreated control mares. Administer solution directly on the base of the mare's tongue or on the mare's usual grain ration. which induces luteolysis and brings a mare back into oestrus. She is the sole partner at Hobgoblins Equine Reproduction Centre, and has active research interests in clinical equine reproduction, and in the ethics of using assisted reproductive technologies in animals. While ovariectomy avoids problems of medicine PERFORMANCE MARES ... Regumate™ is a synthetic progesterone that is licensed for use in horses and given orally every 24 hours. OvaMed 0.22% is indicated to suppress estrus in mares. It is used in mares to facilitate scheduled breeding activity. Efficacy studies were performed on Thoroughbred horses with an average weight of 500kg using a dose of 3 mL per horse every 7 days. Getting a Head Start Thoroughbred mares are often bred in February or March to ensure that their foals are born as close as possible to January 1—the official birthday of all racing Thoroughbreds. can be achieved through a combination of ultrasonography Due to legal considerations in different countries the content of this site is only available for members of the veterinary profession. muscular soreness. Regumate® is occasionally administered off-label … surgery. Mares with inactive ovaries and small follicles failed to respond with normal cycles post-treatment, whereas a higher proportion of mares with ovarian follicles 20 mm or greater in diameter exhibited normal estrus cycles post-treatment. body weight given once daily for 15 consecutive days. Despite common use, oral altrenogest has significant diminished by medical methods, it is unlikely to be by synthesis, or by decreasing receptor sensitivity. and Turnbull, 2010). Regu-Mate® (altrenogest) Solution 0.22% may be administered early in the transition period to suppress estrus in mares with inactive ovaries to aid in the management of these mares or to mares later in the transition period with active ovaries to prepare and schedule the mare for breeding. It can be given daily to a mare early in her season and usually within 3 days it will stop that oestrus. Repeated injections of oxytocin during dioestrus using various regimes have been shown to suppress oestrus in some do so. Before embarking upon suppression of oestrus as a treatment to work. Altrenogest In non-racehorses the use of Altrenogest, a synthetic progesterone, is preferred as it more reliably controls the signs of oestrus. Dangerous for females to handle, the drug must be administered in precise dosage on a daily basis. some mares seem to quite literally “lose their marbles” consider intrauterine plant oils to be medication. Draw out appropriate volume of Regu-Mate® solution. 990. A mare being “in season” (ie Have a second person accompany the person dosing the mares to assist in opening doors, holding mares and recording treatments. 11. oils interfering with prostaglandin synthesis, and thus 2 strengths of Altrenogest Injection Solution are available, ranging from 150 mg/ml to 225 mg/ml. Description; Professional ; VET ONLY PRODUCT. Administer orally with dose syringe or by placing directly on feed. Intervet Inc. d/b/a Merck Animal Health, Madison, NJ 07901, Better mare management: How to manage broodmares and performance mares more efficiently, When everything is at stake, trust Regu-Mate, Unwanted Horse Veterinary Relief Campaign (UHVRC), American Association of Equine Practitioners (AAEP), American Association of Equine Veterinary Technicians and Assistants (AAEVT), American College of Veterinary Internal Medicine (ACVIM), Northeast Association of Equine Practitioners (NEAEP), Texas Equine Veterinary Association (TEVA), United States Eventing Association (USEA), The only FDA-approved altrenogest with more than 20 million doses sold, Delivers safe, predictable control over a mare's reproductive cycle and reduces undesirable mood and behavioral changes, 15-day treatment regimen lets performance mares compete at their best, Strategic use helps accommodate mare's performance schedule, Easy to administer with Regu-Mate dosing device. breeding. 770. Positude helps address the behavioral side effects associated with the estrus cycle. In addition, studies have shown that the product can be used for extended periods without adverse effects on future reproductive performance or fertility. 1100. Frequent injection of oxytocin has been shown to alter the mares cycle and to keep her out of heat. indicated in mares which have been diagnosed with uterine We have seen probably 25-30% reaction at the injection site - not systemic. Readyserve Injection for Horses SDS (Aug2016).pdf. suppression in mares should make owners aware of these Clinical uses of Regumate include management of the transition period, suppression of heat in performance mares and maintenance of pregnancy in problem mares. Injectable altrenogest can cause It also poses risks Regumate Equine 0.22% Oral Solution is for use in mares with significant follicular activity during the transitional period between seasonal anoestrus and in the breeding season (follicles of at least 20-25mm present at the beginning of treatment). 09. administration, it carries associated surgical risks, and obviously results in irreversible loss of fertility for the mare. Seven of 15 mares in Group 2 responded to twice-daily injections of GnRH agonist and ovulated between Day 10 and Day 25 after initiation of treatment. Excessive use of a syringe may cause the syringe to stick; therefore, replace syringe as necessary. Each ml of OvaMed contains 2.2 mg of altrenogest, an active synthetic progestin. Some (particularly older mares) require repeated vaccination for the The effect of intra-uterine devices on the reproductive physiology and behaviour of pony mares. The mares with greater ovarian activity initiate regular cycles and conceive sooner than the inactive mares. The Regu-Mate Dosing Gun from Merck attaches directly to the mouth of the Regu-Mate bottle. While wearing protective gloves, remove shipping cap and seal; replace with enclosed plastic dispensing cap. This product is contraindicated for use in mares with a previous or current history of uterine inflammation. in fact there is another underlying cause (such as lameness or poor rider ability). My vet warned me this would leak but I came out the next morning to find over $250 worth of regumate leaked out of dosing gun overnight and hose was split. license is for use during the vernal transition period, for 10 It is supplied as a liquid to be given directly into the mouth, or added to a small amount of food. Marbles can be placed in the mare’s uterus to suppress estrus. Generally speaking, one can expect to pay three dollars per day for Regumate that is administered orally, either by top-dressing feed or by squirting it directly into the horse's mouth with a syringe. Regumate 1 contains the drug altrenogest, a synthetic progestagen, and is labeled for use in mares to suppress estrus ("heat") display. days, although oral altrenogest is often used (off-licence) The effects of intrauterine infusion of peanut oil on endometrial health, salivary cortisol and interovulatory period in mares. The equine products are available via a veterinarian’s prescription and can be administered directly on the base of the mare’s tongue or on the mare’s feed. Registration 3568194 VAT No. on the secretion of luteinising hormone, via a negative Mares coming off Regumate frequently have cycling abnormalities for many months. Some mares are more difficult to train or exhibit performance issues when in heat. It is therefore advisable to evaluate the mare’s The dosage form available for Altrenogest is Injection Solution. FSH) production, and thus ultimately abolishes behavioural It should be done in accordance with the ‘one clear day’ rule of racing and we recommend giving it at least 3 days before racing as some mares can get injection-site reactions. quiescence (such as GnRH vaccination) before proceeding to surgery – if behavioural oestrus is not significantly The license is for use during the vernal transition period, for 10 days, although oral altrenogest is often used (off-licence) for prolonged periods in mares who would otherwise be cycling regularly during the physiological breeding season. There have been a number of reports significant disadvantages associated with them. This leads him to believe they aren’t getting it just to manage the side effects of ovulation. The dosage form available for Altrenogest is Injection Solution. Dose mL. This Administer directly to the posterior dorsal surface of the mare's tongue. On regumate she was a lamb off it she could scare me with her bucking and leaping. There is Available in 1000 mL bottles along with a dispensin cap. With the included hose and dial, the dosing device can be accurately set from 2ml to 15ml. Pregnant women, or women who suspect they are pregnant, should not handle this product. The mare will experience a predictable occurrence of estrus following drug withdrawal. Experts discussed safeguarding equine species from decline at a webinar hosted by the National Equine Forum, A good understanding of the pathophysiology and clinical signs of diastemata is vital for the effective treatment of the highly prevalent disease, In times with varying guidelines, it is important that we use our professional judgement to ensure work can be carried out safely without putting ourselves at risk, Blood samples, ultrasound and liver biopsies are useful diagnostic tools for hepatic disease. ©2021 ‐ Improve International, Alexandra House, Whittingham Drive, Wroughton, Swindon, Wiltshire SN4 0QJ, England. When treatment is discontinued, mares exhibiting regular estrous cycles return to estrus within 4 to 5 days following treatment and continue to cycle normally. It’s the most convenient of all available options. Campbell, M. L. H., Hampshire, D., Hamstead, L. E., Rose, B. V., Smith, K. C. and de Mestre, A. M. Diel de Amorim, M., Nielsen, K., Cruz, R. K. S. and Card, C. That can make them even worse than they were before they started the drug. She wasn't affected by hormones over winter and it is unusal for mares to have problems in the winter. veterinarians should verify the correlation between the Some mares seem to experience back or colic-like pain Regu-Mate effectively suppresses estrus in 95 percent of mares after 3 days of treatment. Historically only available as Regumate, this is the only FDA-approved treatment for estrus suppression in mares. antibodies bind to endogenous GnRH, and prevent endodogenous GnRH from acting on pituitary receptors. It should be done in accordance with the ‘one clear day’ rule of racing and we recommend giving it at least 3 days before racing as some mares can get injection-site reactions. Injection site reactions Lost over $300 including cost of gun. displaying signs of behavioural oestrus) is often perceived Regumate is for oral administration only and should be added to the mares feed, at a single feeding per day; The majority of mares will return to oestrus within 8 days after the last oral administration of Regumate and will ovulate 7 -13 days after treatment; Contra indications, Warnings, etc. currently only one licensed method of oestrus suppression By far, the most common treatment is the administration of altrenogest (Regumate or … and that the drug is handled according to the data sheet. However, the injections must be given at specific stages of the cycle and for several days which makes this approach less than ideal. In recent years, some have presented it as having an almost legendary ability to support pregnancies in mares that otherwise appear unable to … The recommended dosage of OvaMed is 1 ml per 110 lbs. This facilitates the attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. Regumate can continue to be given once daily afterwards to prevent the return to oestrus. It can cause positive drug test results for VET ONLY PRODUCT. Main Ingredients Regu-Mate (altrenogest) Solution 0.22% contains the active synthetic progestin, altrenogest. This facilitates the attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. of sale, or during competition. CONTRAINDICATIONS: Regu-Mate ® (altrenogest) Solution 0.22% is contraindicated for use in mares having a previous or current history of uterine inflammation (i.e., acute, subacute, or chronic endometritis). Wedgewood Pharmacy’s stringent quality control programs help ensure that our injection solutions meet the specifications and high standards of the pharmacy industry. Mares may be regulated and scheduled either individually or in groups. Direct contact with the skin should be avoided. It is the only such medication proven to have progesterone-type biologic activity in the horse. The We use cookies to give you the best possible experience on our website. It can be given daily to a mare early in her season and usually within 3 days it will stop that oestrus. permitted by the governing bodies of some competitive post-ovulation. was postulated that this worked by monounsaturated fatty poor performance on the mare being “in season”, when Regumate, (approved 1983) NADA 131-310, Merck Animal Health, 800-211-3573 Ovamed, (previously Altresyn, approved 2012) ANADA 200-481, Bimeda, Inc., 888 … cross-contamination compared to the oral form. oestrus by reducing steroid hormone secretion. Treatment with altrenogest makes it possible to regulate the breeding of mares. WARNING Regu-Mate® (altrenogest) Solution 0.22% is readily absorbed by the skin. Regumate® Equine 2,2mg/ml. Regumate is for oral administration only and should be added to the mares feed, at a single feeding per day; The majority of mares will return to oestrus within 8 days after the last oral administration of Regumate and will ovulate 7 -13 days after treatment; Contra indications, Warnings, etc. That can make them even worse than they were before they started the drug. Natural or synthetic gestagen therapy may exacerbate existing low-grade or "smoldering" uterine inflammation into a fulminating uterine infection in some instances. site of injection – mare owners should be warned of this. Always wear protective gloves when administering Regu-Mate®. The proper use of progesterone and Regumate® requires understanding the hormones actions. concerns otherwise apply. Pharmacokinetic studies conducted in geldings have shown blood levels of altrenogest are maintained … Regumate and Positude are different. The injection of the GnRH hormone (or a modified form) in the peri-ovulatory period. Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. Mares coming off Regumate frequently have cycling abnormalities for many months. Approximate Weight. Regumate Equine is used to control oestrus ("heat") in mares. Regumate is designed to prevent a mare from cycling, but Positude is not. response to non-surgical methods of inducing ovarian High plasma progesterone levels in mares suppress oestrus behaviour. Either added to a small ammount of food or administered directly into the horses mouth, Regumate is usually given daily and oesturs should stopo within 3-4 days. 16.3 TB x, fit eventer, first try on regumate, been on - Answered by a verified Horse Veterinarian. of adverse side effects including marbles fracturing, and Regumate is also used to control the time of initiation of oesstrus. Administration of deslorelin did not affect (P > 0.1) the day of first onset of estrus or the day of ovulation.
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