Amlodipine besylate (Norvasc ®) is a prescription medication known as a calcium channel blocker.It is used to treat high blood pressure (hypertension) and certain types of heart disease.The effects of an overdose with amlodipine will vary, depending on a number of factors, including how much amlodipine was taken and whether it was taken with any other medicines, alcohol, and/or drugs. Objectives: The purposes of this study were to describe amlodipine poisoning in children and to determine whether a dose-response relationship could be detected in this population using standardized call data from United States (US) poison centers. Coadministration of simvastatin with amlodipine increases the systemic exposure of simvastatin; Limit simvastatin dose in patients on amlodipine 20 mg/day; Immunosuppressants. Amlodipine oral tablet is a prescription medication used to treat high blood pressure, coronary artery disease, and angina (chest pain). Some CCBs can also cause a fast heart rate as a result of the low blood pressure. Amlodipine's safety in pregnancy has not been established, although reproductive toxicity at high doses is known. This often causes a slow heart rate and low blood pressure. Reports of intentional and accidental amlodipine overdose have resulted in adverse side effects and death. Calcium channel blocker toxicity is the taking of too much of the medications known as calcium channel blockers (CCBs), either by accident or on purpose. No evidence of teratogenicity or other embryo/fetal toxicity was found when pregnant rats and rabbits were treated orally with amlodipine maleate at doses up to 10 mg amlodipine/kg/day (approximately 10 and 20 times the MRHD based on body surface area, respectively) during their respective periods of major organogenesis. Amlodipine is a type of long-acting dihydropyridine CCB. No evidence of teratogenicity or other embryo/fetal toxicity was found when pregnant rats or rabbits were treated orally with amlodipine maleate at doses up to 10 mg amlodipine/kg/day respectively 8 times* and 23 times* the maximum recommended human dose of 10 mg on a mg/m 2 basis) during their respective periods of major organogenesis. The usual initial antihypertensive oral dose of amlodipine is 5 mg once daily, and the maximum dose is 10 mg once daily. 1-3 According to Micromedex, while a specific dose for amlodipine toxicity has not been established, patients who ingest greater than 10 mg may develop toxicity and should seek medical attention. 1994). [Medline] . Whether amlodipine enters the milk of breastfeeding mothers is also unknown. The toxic doses of amlodipine in children are unclear. The average concentration of amlodipine after 14 repeated oral doses of 15 mg given once daily is 14.5±5.8 ng/ml measured the last day (Faulkner et … angina or cardiac arrhythmias. 2010 Aug. 39(2):186-93. Don't delay your care at Mayo Clinic. This can progress to the heart stopping altogether. At therapeutic doses, this class of CCBs act predominantly on L-type calcium channels on vascular smooth muscle cells with little effect on the myocardium.2 Amlodipine is commonly prescribed for hypertension given its favorable adverse effect profile J Emerg Med . Amlodipine appears to have a linear pharmacokinetic profile; the dose is correlated with the mean peak plasma concentration (Clavijo et al. Those who have heart failure, or recently had a heart attack, should take amlodipine with caution. It's a type of drug called a calcium channel blocker. Schedule your appointment now for safe in-person care. Amlodipine toxicity in children less than 6 years of age: a dose-response analysis using national poison data system data. Amlodipine may increase systemic exposure of cyclosporine or tacrolimus when coadministered

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