Talk to your veterinarian about proper use and safe handling of Regu-Mate®. A review of the indications for oestrus suppression in mares, including the pros and cons of various treatment options. The injection of the GnRH hormone (or a modified form) Resolution of swelling was usually 3-4 days. Regumate Equine is used to control oestrus ("heat") in mares. The technique works with about 50% of non-cycling mares. breeding. The Getting a Head Start Thoroughbred mares are often bred in February or March to ensure that their foals are born as close as possible to January 1—the official birthday of all racing Thoroughbreds. mare may suppress oestrus behaviour, but does not always was postulated that this worked by monounsaturated fatty Some mares are more difficult to train or exhibit performance issues when in heat. mares (Gee et al., 2012; Vanderwall et al., 2016). My vet warned me this would leak but I came out the next morning to find over $250 worth of regumate leaked out of dosing gun overnight and hose was split. A number of medications and ... (Regumate ®) once daily for 6 weeks. It is crucial that horse managers are aware of these risks, ©2021 ‐ Improve International, Alexandra House, Whittingham Drive, Wroughton, Swindon, Wiltshire SN4 0QJ, England. For complete product information, see accompanying product insert. It is supplied as a liquid to be given directly into the mouth, or added to a small amount of food. Regumate Equine 0.22% Oral Solution is for use in mares with significant follicular activity during the transitional period between seasonal anoestrus and in the breeding season (follicles of at least 20-25mm present at the beginning of treatment). ADDITIONAL INFORMATION: A 3-year well controlled reproductive safety study was conducted in 27 pregnant mares, and compared with 24 untreated control mares. Regumate® is a man made progestane, altrenogest, that has strong progesterone properties and can be placed in the feed. REGU-MATE (altrenogest) Solution 0.22% is indicated to suppress estrus in mares. More likely is that it was just one of those cascade of events that resulted in a pregnancy loss. Getting a Head Start Thoroughbred mares are often bred in February or March to ensure that their foals are born as close as possible to January 1—the official birthday of all racing Thoroughbreds. Regu-Mate can help alleviate moodiness and temperament changes associated with estrus. Other altrenogest products are also marketed, however "Regumate" tends to be used as the catch-all name as a result of being the … Preventing Estrus In Performance Mares. There is PERFORMANCE MARES ... Regumate™ is a synthetic progesterone that is licensed for use in horses and given orally every 24 hours. Others enter very prolonged suppression of reproductive cyclicity, or fail to regain ovarian activity at all. On regumate she was a lamb off it she could scare me with her bucking and leaping. Natural or synthetic gestagen therapy may exacerbate existing low-grade or "smoldering" uterine inflammation into a fulminating uterine infection in some instances. for the suppression of oestrus in mares in the UK. It is also commonly used to help maintain pregnancy in mares determined to be at risk of pregnancy loss. Twelve days of Regumate (an oral progesterone) followed by a Prostin injection. have been reported. “The reality is that many of these mares that are on it every day for months and months, it’s not a … Equine, MSD Animal Health) is the only treatment licensed While wearing protective gloves, remove shipping cap and seal; replace with enclosed plastic dispensing cap. with certain types of tumour and thromboembolic disease. Regumate is the trade name for a synthetic hormone called altrenogest. Regumate Equine is used to control oestrus ("heat") in mares. Mares coming off Regumate frequently have cycling abnormalities for many months. There are ethical issues surrounding failure to 349 7028 73. supplementation with Regumate™ will prevent a mare from coming into season. It is the only such medication proven to have progesterone-type biologic activity in the horse. either by mimicking an embryo moving through the uterus, Injectable altrenogest can cause It antibodies bind to endogenous GnRH, and prevent endodogenous GnRH from acting on pituitary receptors. discolouration of the coat, alopecia and hair thinning at the PRECAUTIONS Various synthetic progestins, including altrenogest, when administered to rats during the embryogenic stage of pregnancy at doses manyfold greater than the recommended equine dose caused fetal anomalies, specifically masculinization of the female genitalia. The proper use of progesterone and Regumate® requires understanding the hormones actions. Treatment with altrenogest makes it possible to regulate the breeding of mares. Altrenogest In non-racehorses the use of Altrenogest, a synthetic progesterone, is preferred as it more reliably controls the signs of oestrus. Removal of marbles when of adverse side effects including marbles fracturing, and Registration 3568194 VAT No. present when treatment was initiated. There is no GnRH vaccine currently licensed in the UK. A mare being “in season” (ie The recommended dosage of OvaMed is 1 ml per 110 lbs. How to calculate dosage of porcine regumate for mare? It can be given daily to a mare early in her season and usually within 3 days it will stop that oestrus. administration, it carries associated surgical risks, and obviously results in irreversible loss of fertility for the mare. 16.3 TB x, fit eventer, first try on regumate, been on - Answered by a verified Horse Veterinarian. 12 . cycling regularly during the physiological breeding season. Pros: The GnRH vaccine is very effective, and requires only one injection every year. We use cookies to give you the best possible experience on our website. Regu-Mate effectively suppresses estrus in 95 percent of mares after 3 days of treatment. uterine infusion of plant oils causes at least a temporary Progesterone for 14 days (Regumate or IM injection of progesterone) Progesterone (or P+E) for 7 days or long acting progesterone (1 injection), PGF2a on day 7 ; PGF2a: single injection (mares are responsive only when there is a functioning CL present: day 5-12 of cycle, 80% of mares respond) It’s the most convenient of all available options. 07. post-ovulation. When treatment is discontinued, mares exhibiting regular estrous cycles return to estrus within 4 to 5 days following treatment and continue to cycle normally. Management. nor reliable method of suppressing oestrus in mares (Argo D. Frisina. Regumate 1 contains the drug Altrenogest, a synthetic progestagen, and is labeled for use in mares to suppress estrus (heat) display. Injection site reactions Available in 1000 mL bottles along with a dispensin cap. Detach syringe and administer solution orally at the rate of 1 mL per 110 pounds body weight (0.044 mg/kg) once daily for 15 consecutive days. indicated in mares which have been diagnosed with uterine This is appropriate for the mare not showing at all or showing heat but not developing follicles. Madeleine Campbell, BVetMed, MA (Oxon), MA (Keele), Phd, DipECAR, DipECAWBM, MRCVS, is a RCVS and European Recognised Specialist in Equine Reproduction. Administer directly to the posterior dorsal surface of the mare's tongue. Each ml of OvaMed contains 2.2 mg of altrenogest, an active synthetic progestin. Treatment with altrenogest makes it possible to regulate the breeding of mares. fractionated coconut oil nor peanut oil reliably suppressed or by mildly damaging the endometrium. the suppression of oestrus in mares. Regu-Mate ® (altrenogest) Solution 0.22% is indicated to suppress estrus in mares. The dosage form available for Altrenogest is Injection Solution. as a problem by owners, who feel that it makes the mare permitted by the governing bodies of some competitive Some mares are more difficult to train or exhibit performance issues when in heat. treatment to work. fractionated coconut oil or peanut (arachis) oil at day 10 Dangerous for females to handle, the drug must be administered in precise dosage on a daily basis. Dose mL. Copyright © 2021 Intervet Inc., a subsidiary of Merck & Co., All Rights Reserved. Monthly injectable Altrenogest is available at greater cost. However, the injections must be given at specific stages of the cycle and for several days which makes this approach less than ideal. Many show mares are on it year round and at a higher dose than the recommended amount. Efficacy studies were performed on Thoroughbred horses with an average weight of 500kg using a dose of 3 mL per horse every 7 days. Prostaglandins are given in an intramuscular injection; if given IV, the mare will collapse and convulse, which can be life threatening. Should an accidental contamination with Regu-Mate® occur, wash off the contaminated area with soap and water. In recent years, some have presented it as having an almost legendary ability to support pregnancies in mares that otherwise appear unable to … Regumate is also used to control the time of initiation of oesstrus. Mares may be regulated and scheduled either individually or in groups. and Turnbull, 2010). The single testing of a progesterone level. CONTRAINDICATIONS Regu-Mate® (altrenogest) Solution 0.22% is contraindicated for use in mares having a previous or current history of uterine inflammation (i.e., acute, subacute, or chronic endometritis). synthesis, or by decreasing receptor sensitivity. in fact there is another underlying cause (such as lameness or poor rider ability). The downside, as with any injection you have to give repeatedly, is the risk that some mares 1210. This article discusses the actions of these hormones and their use in equine medicine and reproduction. Excessive use of a syringe may cause the syringe to stick; therefore, replace syringe as necessary. High plasma progesterone levels in mares suppress oestrus behaviour. This injection is used for managing the brood mares estrous cycle & breeding efficiency. It is supplied as a liquid to be given directly into the mouth, or added to a small amount of food. quiescence (such as GnRH vaccination) before proceeding to surgery – if behavioural oestrus is not significantly Administer Regu-Mate® separately from other treatments. Regumate Equine is a liquid suspension used for the suppression or prevention of oestrus in mares. Lösung zum Eingeben für Pferde – Gestagen wirksames Hormon (Altrenogest) Zusammensetzung. On regumate she was a lamb off it she could scare me with her bucking and leaping. plus an adjuvant induces GnRH antibody formation. This facilitates the attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. Regumate and Positude are different. Regu-Mate® (altrenogest) Solution 0.22% is indicated to suppress estrus in mares. The effect of intra-uterine devices on the reproductive physiology and behaviour of pony mares. It is therefore important, before response to vaccination. in-contact horses via feed contamination. Regumate can cause temporary infertility, which will last for a while even after you stop administering it, so bear that in mind if you want to breed the mare. Progesterone levels and days to luteolysis in mares treated with intrauterine fractionated coconut oil. mare being in oestrus and the occurrence of the episodes Direct contact with the skin should be avoided. Regumate™ is very effective and easy to use. This article is the first in a series on the efficacy of medications or techniques used in mares to suppress heat. Injection with human chorionic gonadotrophin has also can be achieved through a combination of ultrasonography et al., 2016; Campbell et al., 2017) reported that neither Both papers also suggested that intra- been used as a method of suppressing oestrus in mares. Description; Professional ; VET ONLY PRODUCT. She wasn't affected by hormones over winter and it is unusal for mares to have problems in the winter. The same Regumate® is occasionally administered off-label … days, although oral altrenogest is often used (off-licence) One paper reported that intrauterine infusion with either injections, which may produce injection site reactions and Equally, mare owners often blame behavioural issues or Campbell, M. L. H., Hampshire, D., Hamstead, L. E., Rose, B. V., Smith, K. C. and de Mestre, A. M. Diel de Amorim, M., Nielsen, K., Cruz, R. K. S. and Card, C. Marbles can be placed in the mare’s uterus to suppress estrus. 15-day treatment regimen allows performance horse to compete at their best. Suppression of sexual behavior in mares is much more common than in stallions. WARNING Regu-Mate® (altrenogest) Solution 0.22% is readily absorbed by the skin. Before embarking upon suppression of oestrus as a equine sports, and others require special permissions for 08. We were recommended to use Regumate (this was the first suggestion before marble, but i worried about the not touching thing, and thought marble was cheaper option) I had a ball for a long time with my mare, so much more like she used to be before her hormones kicked in, calm, ridable, SAFE! 2 strengths of Altrenogest Injection Solution are available, ranging from 150 mg/ml to 225 mg/ml. It is procured from authentic vendors in the market who are commended for their product quality since several years. It is therefore advisable to evaluate the mare’s Some mares seem to experience back or colic-like pain Some sports governing bodies may require ovariectomy to Merck Animal Health US. for prolonged periods in mares who would otherwise be license is for use during the vernal transition period, for 10 muscular soreness. Regumate® Equine 2,2mg/ml. Altrenogest is used for suppression of estrus. 3. The What we don’t know is how many have not or if it takes longer to establish normal cycles and conception rates after long-term Regumate use. The equine products are available via a veterinarian’s prescription and can be administered directly on the base of the mare’s tongue or on the mare’s feed. : Not to be administered to male animals Helpful. It has been reported in one study using a small number of Other organisations, such as the FEI, do permit mares to compete on Regumate. 2 strengths of Altrenogest Injection Solution are available, ranging from 150 mg/ml to 225 mg/ml. The ... muscular injection, and then received 400 mg once per week for an additional 5 weeks. Certainly mares have been withdrawn from Regumate and successfully bred. ... A single injection will be effective for anywhere from six to 24 months. The oral synthetic progestin altrenogest (Regumate The use of altrenogest may exacerbate endometrial infection if a low level of (sometimes undiagnosed) infection was All the methods described above have of sale, or during competition. Regumate can continue to be given once daily afterwards to prevent the return to oestrus. Either added to a small ammount of food or administered directly into the horses mouth, Regumate is usually given daily and oesturs should stopo within 3-4 days. be declared. Administer orally with dose syringe or by placing directly on feed. No part of this site may be reproduced without permission. declare the insertion of an intrauterine marble at the time Altrenogest. Oral altrenogest is no longer under patent, and is now available from several different manufacturers. Regumate® is a man made progestane, altrenogest, that has strong progesterone properties and can be placed in the feed. consider intrauterine plant oils to be medication. The proper use of progesterone and Regumate® requires understanding the hormones actions. It is marketed under several brand names, including the equine products Regumate, Ovamed and Altren; and the swine products Matrix, Chronomate and Swinemate. the marble blocked the release of PGF2α from the uterus, The Regu-Mate Dosing Gun from Merck attaches directly to the mouth of the Regu-Mate bottle. Regumate is also used to control the time of initiation of oesstrus. Main Ingredients Regu-Mate (altrenogest) Solution 0.22% contains the active synthetic progestin, altrenogest. It should be done in accordance with the ‘one clear day’ rule of racing and we recommend giving it at least 3 days before racing as some mares can get injection-site reactions. There have been a number of reports For the suppression of oestrus in normally cycling mares. Replace cover on bottle dispensing tip to prevent leakage. Repeated injections of oxytocin during dioestrus using various regimes have been shown to suppress oestrus in some Most people find that Positude is so effective in addressing their mare’s behavior that they do not need Regumate, but it is ok to use both. Positude helps address the behavioral side effects associated with the estrus cycle. Once verified, there are This must be discussed with the horse (Readyserve, CEVA Animal Health). Its use is contra- In Australia, an injectable form of altrenogest is available injection and 2) mares that received an i.m. Regumate can cause temporary infertility, which will last for a while even after you stop administering it, so bear that in mind if you want to breed the mare. REGUMATE IN STALLIONS – Effects on Reproductive Performance Patrick M. McCue DVM, PhD, Diplomate American College of Theriogenologists Regumate® or altrenogest is a synthetic progestin approved for suppression of estrus in mares. This may result in reduced functionality and affect the graphical presentation of this site.However, all content will still be available. This article discusses the actions of these hormones and their use in equine medicine and reproduction. May be worth trying a bottle of regumate to see if it helps and if it does then work out whether injection or regumate would be better. READYSERVE ALTRENOGEST INJECTION FOR HORSES. veterinarians should verify the correlation between the Regu-Mate ® (altrenogest) Solution 0.22% is indicated to suppress estrus in mares. The day of the major event or stakes arrives and the prize mare is ready to compete. This in the peri-ovulatory period. Intervet Inc. d/b/a Merck Animal Health, Madison, NJ 07901, Better mare management: How to manage broodmares and performance mares more efficiently, When everything is at stake, trust Regu-Mate, Unwanted Horse Veterinary Relief Campaign (UHVRC), American Association of Equine Practitioners (AAEP), American Association of Equine Veterinary Technicians and Assistants (AAEVT), American College of Veterinary Internal Medicine (ACVIM), Northeast Association of Equine Practitioners (NEAEP), Texas Equine Veterinary Association (TEVA), United States Eventing Association (USEA), The only FDA-approved altrenogest with more than 20 million doses sold, Delivers safe, predictable control over a mare's reproductive cycle and reduces undesirable mood and behavioral changes, 15-day treatment regimen lets performance mares compete at their best, Strategic use helps accommodate mare's performance schedule, Easy to administer with Regu-Mate dosing device. In our wide range of products, we are also offering our clients a supreme grade variety of Regumate Equine Oral Solution. Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. While ovariectomy avoids problems of medicine (Note: Do not remove syringe while bottle is inverted as spillage may result.) and serum progesterone analysis. Mares return to heat and release natural hormones again once treatment stops. Approximate Weight. The dosage form available for Altrenogest is Injection Solution. mechanism of oestrus suppression was believed to be that facts, and alert them that sports governing bodies could Regumate (altrenogest) appears to be the safest way to go when seeking to prevent a mare from coming into heat, says Beckman, although it does have a downside--it is expensive. for up to 30 days post-ovulation (Wilsher and Allen, 2011). Repeated injections of oxytocin disrupt this mechanism, probably either by down-regulating oxytocin-receptor By continuing to use this site you consent to the use of cookies on your device as described in our cookie policy unless you have disabled them. oestrus in mares when infused into the uterus at 10 days 1100. Pharmacokinetic studies conducted in geldings have shown blood levels of altrenogest are maintained … 10. It can cause positive drug test results for Administer solution directly on the base of the mare's tongue or on the mare's usual grain ration. 11. Mares return to heat and release natural hormones again once treatment stops. A number of medications and management strategies have been used over the years to prevent estrus in mares. Progesterone also has an inhibitory effect Positude is made from highly concentrated leaf, berry and root extracts that act upon the pituitary to maintain even hormone levels in mares, geldings and stallions. currently only one licensed method of oestrus suppression It is marketed under several brand names, including the equine products Regumate, Ovamed and Altren; and the swine products Matrix, Chronomate … Have a second person accompany the person dosing the mares to assist in opening doors, holding mares and recording treatments. Pregnant women, or women who suspect they are pregnant, should not handle this product. because the treatment fails, they return to oestrus, and the numerous treatment options available. “To inhibit estrous signs you would give the injection daily or weekly, depending on the formulation. Either added to a small ammount of food or administered directly into the horses mouth, Regumate is usually given daily and oesturs should stopo within 3-4 days. This allows a regular cycle during the transition from winter anestrus to the physiological breeding season in mares with active ovaries. Injectable altrenogest can cause discolouration of the coat, alopecia and hair thinning at the site of injection – mare owners should be warned of this. Lost over $300 including cost of gun. It is generally accepted that when mares are in estrus (heat) there performance may not be as good as when they are out of heat. Initially, a series of two injections is required, with annual boosters recommended to keep your mare from cycling. post-ovulation suppressed oestrus in the majority of mares This injection is used for managing the brood mares estrous cycle & breeding efficiency. ... Regumate Dosage Chart. Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. owner/manager. Regumate 1 contains the drug altrenogest, a synthetic progestagen, and is labeled for use in mares to suppress estrus ("heat") display. CONTRAINDICATIONS: Regu-Mate ® (altrenogest) Solution 0.22% is contraindicated for use in mares having a previous or current history of uterine inflammation (i.e., acute, subacute, or chronic endometritis). If hormones are a problem and something like regumate does help you will notice a difference by the end of the first week. Suppression of estrus may be used to facilitate scheduled breeding during the physiological breeding season. 1320. of pain/undesirable behaviour/poor performance. Despite common use, oral altrenogest has significant A GnRH vaccine (Equity, Zoetis) is licensed in Australia for FWIW ... we stand by our Regumate however, some clients like to do their own thing, and if it works for them and isn't harmful that's fine with me. Experts discussed safeguarding equine species from decline at a webinar hosted by the National Equine Forum, A good understanding of the pathophysiology and clinical signs of diastemata is vital for the effective treatment of the highly prevalent disease, In times with varying guidelines, it is important that we use our professional judgement to ensure work can be carried out safely without putting ourselves at risk, Blood samples, ultrasound and liver biopsies are useful diagnostic tools for hepatic disease. Mimicking the effects of progesterone therapy, Positude is safe to handle, easy to feed, and its daily delivery system eliminates peaks and troughs of hormonal fluctuations That study you sent they only gave the mares 1600mg of Medroxy. The main poor performance on the mare being “in season”, when surgery. Always wear protective gloves when administering Regu-Mate®. It is also used to suppress estrous behavior in performance horses.