Currently beside fluvoxamine, there is research being done on colchicine (usually used for gout), ivermectin (controversial because the main people promoting it believe so strongly in it that they flat out say on their website it is unethical to perform randomized control trials to study it at this point, which is bonkers), various vitamins have been proposed. Now, a lot of people are deficient -- probably more now than usual due to the lock down because people aren't getting out much, so people are getting less sun exposure. (1) False Cause — “Presuming that a real or perceived relationship between things means that one is the cause of the other.” (related: correlation does not imply causation, or in xkcd form) For every study that shows statistically significant results, there may have been many similar tests that were inconclusive. First, notice that extrapolation is : the process of estimating, beyond the original observation range, the value of a variable on the basis of its relationship with another variable. He thinks he drew this one to get back at people going through his stuff. We don't even know if sigma-1 is responsible for the effects observed, but it wouldn't make sense to give someone Fluoxetine instead of Fluvoxamine (which is also widely available), especially when it would require overdose levels of Fluoxetine to achieve similar sigma-1 effects. It makes me wonder - or seems to insinuate to - that Fluvoxamine may directly impact the immune system. There are a large number of people who believe that the reason we don't use HCQ is due to a conspiracy. Is there something specific that's wrong with their math? [0] https://www.healthline.com/nutrition/vitamin-d-side-effects. 95% Confidence [[Back to the original two.]] Goggles: We found no link between yellow jelly beans and acne (p > 0.05). ", If you tell them the second thing, the entire world will rise up and go "You are so full of shit. It became obvious that it didn't matter whether patients got it or not in my experience (some got better and some died whether or not they got it), numerous studies then confirmed this. 345: You'd make a wonderful dread pirate, Roberts. Oral vitamin D has been shown to be ineffective at this point, but this isn't surprising: it takes a long time of sustained oral supplementation to raise levels. I've tried zinc once, (again, pre covid days), and I guess I kicked whatever I was about to get. Goggles: We found no link between yellow jelly beans and acne (p > 0.05). Maybe our mental models of what is going on there will evolve and what I am saying will be "the obvious answer" to future generations, but it's not what is currently believed to be what works to solve obesity. [[20 near identical small panels follow, 4 rows 5 columns.]] There are a lot of people who are invested in being right for various reasons rather than trying to find the truth, and many of these websites are biased. We know that the amounts they recommend are completely long term safe for everyone and long term good enough to avoid severe deficiency. Dating in Germany will either make it more so or raise the chance to … https://www.medrxiv.org/content/10.1101/2020.11.16.20232397v... (Yes, the RCT uses cholecalciferol instead of calcifediol, so the reason why the intervention did not work may be that its a bit late. There as so many factors including diet, body composition, sunlight exposure, genetics, etc. Unfortunately, HCQ became politicized which added a bunch of noise. Previous studies have shown that fluvoxamine, a selective serotonin reuptake inhibitor (SSRI) with high affinity for the S1R reduced damaging aspects of the inflammatory response during sepsis through the S1R-IRE1 pathway, and decreased shock in murine sepsis models. We just don't know. > Just over two-thirds of Canadians (68%) had blood concentrations of vitamin D over 50 nmol/L -- a level that is sufficient for healthy bones for most people. However, it's possible that the anti-COVID properties are unrelated to Fluvoxamine's actions at the serotonin transporter or the sigma-1 receptor. “ Keep in mind that Hydroxychloroquine is one of the existing drugs discovered to have some effect on early infections, but it clearly failed to have much impact on late-stage infections”. The drug in particular is fluvoxamine, a potent selective serotonin reuptake inhibitor (SSRI). It doesn't prevent the hospitalization, it prevents the symptoms that lead to hospitalization. However, significant results are more interesting to read about and are therefore more likely to get published. You know basically vitamin D is a kind of "master regulator" of metabolism / immune system. So my experience fits with the general idea that "Solving obesity is harder than it looks and the solution may be something non obvious in any given case." by which this person meant the child's maintenance drugs were the same. https://docs.google.com/presentation/d/1u7resy2bGA1_HIgj6Nc7... https://www.jstage.jst.go.jp/article/bst/advpub/0/advpub_202... https://www.google.com/amp/s/www.nytimes.com/2021/01/08/heal... https://pubmed.ncbi.nlm.nih.gov/24508523/. But these are not answers people want to hear. Why Quark Rhymes with Pork: And Other Scientific Diversions By N. David Mermin Cambridge University Press (January 2016) The content of many non-fiction books can be summarized as “the blurb spread thinly,” but that’s a craft which David Mermin’s new essay collection Why Quark Rhymes With Pork cannot be accused of. People tend to not get excited about the idea that treating nutritional deficiencies helps shore up your body's ability to fight disease, even in cases where that deficiency is fairly widespread and the disease in question is fairly deadly. This doesn't mean that other antidepressants will work (if fluvoxamine really does work in larger trials). Of particular interest, he links to Washington University's large-population, remote trial of fluvoximine that's free and anyone can apply and participate from home. So can the conclusion be that vitamin D does not work as expected? 200 sounds quite reasonable. Goggles: We found no link between black jelly beans and acne (p > 0.05). The expectation is that these studies would show little benefit, and indeed that is the case. Ponytail: I hear it's only a certain color that causes it. The relevant passage is below. I’m interested in what you think that paper says? When you do this, it forces you to critically think about how best to rank these and how that ranking might change with evidence. Which just seems to go against the available evidence at this point. The issue is further complicated by the interaction with other micronutrients such as calcium and vitamin K. Vitamin D intake has to be adjusted based on those as well. -- waste of water and electricity. Apparently it is used along with Vitamin D. So if you find yourself in my situation, talk to your doctor. So I've mostly quit trying to talk about "Things you -- yes, you as an individual -- can do to try to cope with this global pandemic." There's a lot of ignorance and prejudice and inherent resistance to resolving medical things nutritionally. There's a bunch of very professional-looking websites claiming the effectiveness of HCQ, especially early on : EDIT: Also note that those links are all the run by the same group, the FAQs are the same. Goggles: We found no link between teal jelly beans and acne (p > 0.05). I think there may somewhat less excitement about it because it helps if you are deficient but not if you are not, so it fails to serve as a drug substitute. '}}, xkcd.com is best viewed with Netscape Navigator 4.0 or below on a Pentium 3±1 emulated in Javascript on an Apple IIGS, Creative Commons Attribution-NonCommercial 2.5 License. Ponytail: Jelly beans cause acne! There's no single answer. I agree it's terrible web design, but like many such cases, it can be fixed by enabling Firefox's Reader View. i suspect a tiny dose of antiviral or synthetic antibody would be effective for prophylaxis or early treatment. Remdesivir maybe decreases length of stay in the hospital. Because I know many studies that showed no benefit, for example: https://www.nejm.org/doi/full/10.1056/nejmoa2016638. This work is licensed under a This. See: Respectfully, that's just a counter. Mental health and the type of social media use: Active, Passive, Positive, & Negative. About 32% of Canadians were below the cut-off. I have a serious medical condition and I know what the path not taken is supposed to look like and I've been getting better for nearly two decades when the condition is supposed to involve a steady and irreversible decline and I get told all the time that I am full of baloney and I can't possibly know that what I'm doing is effective and "X number of years of steady forward progress is just a wild coincidence -- stranger things have happened" and on and on. The pandemic concerns the work and lives of just about any doctor at the moment. Other things: Tips on technology and government, Climate FAQ , Katharine Hayhoe xkcd.com is best viewed with Netscape Navigator 4.0 or below on a Pentium 3±1 emulated in Javascript on an Apple IIGS I would totally take it, but I wouldn't be very surprised if I still got a severe disease. The reasons for UK health services failing have little or no connection to vitamin D. The amount recommended is insufficient for most people to get to the level where (correlation) has shown significantly reduced risk - that is >30 ng/ml (>75 nmol/l), Please see Vitamin D public health campaign petition. efficacy in treatment of COVID-19 associated pneumonia in I believe the studies, but my question is why do we let the health system suffer if there is such a simple solution? But zinc is another thing that looks promising from what I gather. Basically it's a funnel, so It takes testing a large amount of people to tease out just a handful of infections. Apologies if I did. I've been trying to lay low and not crab at people online. However, while I had found these arguments compelling, the issue was that they took the effectiveness of HCQ as a starting point. . I’m not sure what you’re implying. 10k IU/day exceeds the Tolerable Upper Intake as determined by the US's National Academy of Medicine, the European Food Safety Authority, and similar organizations. The problem is the confirmed cases are the primary part of determining efficacy. They get updated fairly regularly and are composed of the boots on the ground infectious disease specialist physicians who are trying to help people. Good day, sir. > Of 50 patients treated with calcifediol, one required admission to the ICU (2%), while of 26 untreated patients, 13 required admission (50 %) p value X2 Fischer test p < 0.001. I will say, I've been regularly taking Vitamin D for a while and recently started having some low back pain. Anyone who is really interested in their own welfare can and should start a food and symptom journal and read, read, read about health stuff (and learn how to sort the wheat from the chaff). It is, however, a non-reviewed preprint. The trouble with that approach is that we don't really know the optimal vitamin D level for human health. As of now, the data is still insufficient to be conclusive (which he highlights) but I appreciate they are sharing these kind of insights from the front lines, at least for those capable of understanding the nature of evolving research and the associated uncertainties. Pfizers stage 3 vaccine trial have 41,000 participants. It pretty much is a slam dunk solved problem to say "If you are deficient in X, redress that." Not saying this is a result that should be taken as definite, but it's strong enough to warrant further looking into this (which was never really true for hydroxychloroquine). Talked to the doctor and was told to take some magnesium. Nope. I'm not at my best today. Antibiotics routinely cause diarrhea and that's one of the more common side effects of alternative remedies, yet if I tell people that many of them will use that as an excuse to say "Oh, it has side effects. and stuff like that. This post and related posts about vitamin D were discussed on HN. Other papers had means and SDs that were impossible given the range. Are you unconvinced? For optimal results, do not consume calcium and iron together. I'm pretty damn sure I will survive this -- unless I stupidly try to be helpful, in which case an angry mob may decide I am somehow to blame for something. There is link that it is being used in clinical trials, but no results. 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